Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00192 |
CD32B Protein, Human, Recombinant (His)
FCG2,IgG Fc Receptor II-... |
Human | HEK293 Cells |
FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM)... | |||
TMPJ-00803 |
CD32B Protein, Mouse, Recombinant (His)
Fcgr2,Fcgr2b,Fc-γ-RIIB,<... |
Mouse | HEK293 Cells |
Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therap... | |||
TMPJ-00446 |
CD32A Protein, Human, Recombinant (R167, His)
FcRII-a,IGFR2,Low Affinity |
Human | HEK293 Cells |
Receptors for the Fc region of IgG (FcγR) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human FcγRs are divided into three classes designated FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16), which generate multiple isoforms, are recognized. The activating type receptor either has or associates noncovalently with an accessory subunit that has an immunoreceptor tyrosinebased activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG... |